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The fact that the mother gave up custody of her other children certainly would help him in his attempt to gain custody because she's already shown an unwillingness to care for her children.
The court always does what is in the best interest of the child....so if your son can prove that he's ready, willing and able to take custody -- and that he has the ability and resources to house and care for the child -- then he should be in a good position to take custody of the child....especially since the mother has relinquished her rights over her other children.