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Does brother have a medical power of attorney or just a general power of attorney?
Is mother suffering from any kind of illness or disability that would make her mentally incompetent?
Do you have reason to believe mother is in danger?
Ok, from a purely legal perspective, if they have a medical POA, and mother is unable to make medical or care decisions on her own, then they would have the legal authority to admit her to a care facility if she needs more intensive care than can be provided at home.
At this point if you have have reason to think she is in danger, you could contact the local police and ask them to perform a "wellness check" where they will contact brother and sister and obtain information about mother's wherabouts and have local police check in on her.
The only other option to gain control would be to file a formal petition for guardianship in the local probate court where mother last lived and seek to be appointed legal guardian over mother. If you were successful in your petition, you could revoke the POAs and then would have complete control over mother's care and affairs.