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Ask Dr. Dan B. Your Own Question
Dr. Dan B.
Dr. Dan B., Board Certified Ophthalmologist
Category: Eye
Satisfied Customers: 3343
Experience:  Eye surgeon experienced in cataracts, glaucoma, retina & neuro-ophthalmology
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Diagnosed 3 yrs. ago with AMD Wet, followed by 2+ yrs. of

Resolved Question:

Diagnosed 3 yrs. ago with AMD Wet, followed by 2+ yrs. of Avastin needle treatments. Retinal ophthalmologist, being concerned re possible infection from number/frequency of Avastin treatments, changed to Visudyne laser on left (good) eye.. Right eye has stabilized for well over two years, with central vision scarred but good peripheral vision remaining. "Good" left eye retains central vision, sometimes needing 3X magnification for easier reading of paperbacks/newspaper finer print. Since laser treatment 3 months ago, developed mysterious painless swelling of left thigh only. Assuming possible blood clot/other arterial problems, was put thru left leg ultrasound + MRI of both legs, as well as very thorough fasting blood testing. Also had two previous CT scans, one for lungs I'm COPD), other of entire torso. Phlebitis mentioned as one possible side effect in permit I signed jpior to angiogram....possible??? Or Visodyne??? Suggestions for further testing??? M Cheren***@******.***
Submitted: 7 years ago.
Category: Eye
Expert:  Dr. Dan B. replied 7 years ago.

Hello and welcome to

If I may, can I clarify your question?

Are you asking whether having the angiogram itself or the Visudyne may have caused blood clots?

And are you also asking what treatment steps you should take in the future assuming this was a result of the angiogram or Visudyne?

Customer: replied 7 years ago.
No questions re blood clots.....they have been totally ruled out by CT scans of lungs and torso and, particularly, by ultrasound of entire left leg and recent MRI of both legs. My question regards ***** ***** of left thigh only (Visudyne treatment in left eye), no swelling of lower leg(s). 2-inch difference between left thigh and of right thigh circumference. My question, simply, can there be any question of coincidence of swelling particularly re left eye Visudyne treatment of 3 months ago (leg swelling first noticed within several wks.- don't spend much time admiring my 84-yr. olf legs!!!)) possible effect, and/or frequency or accumulated effect of 6-9 fluorein angiographies over last three yrs. Angiographies all done on right arm because of missing nodes from very small breast cancer op in 1995.on left side, so I allow no injections of any sort on left arm as precaution. Never developed any edema as result of that operation and am a 15 yr. survivor..Breast tumor was 11mm, lumpectomy and radiotion for 5 weks summer of 1995. Mammogram this year clear.
Expert:  Dr. Dan B. replied 7 years ago.

Fluorescein angiography can, uncommonly, induce a thrombophlebitis which can cause local swelling, but this is usually limited to the injection site or areas near the injection site. I would not expect an accumulation of fluorescein angiograms to be the culprit for this leg swelling.

Does this answer your question?

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My opinion is solely informative and does not constitute a formal medical opinion or recommendation. For a formal medical opinion and/or recommendation you must be examined by your doctor.

Customer: replied 7 years ago.
Still doesn't answer probabilities of thigh swelling as result of Visudyne treatment, which in brochure given me by ophtholmology doc, on page 24 lists lists, among other adverse reactioons, "Cardiovascular:...... peripheral vascular disorder"; would swollen thigh withut blood clots or any diaagnosed arterial complications qualify? Obviously, I must search further.....I believe in being as much of a proactive patient as possible. Super busy primary doctors don't always have the time to delve into more abstruse symptoms. Thanks for your comments re fluorescein; puzzled by lack of any comment re Visudyne. Of course, recognize there may be no patient reports of symptom such as mine in connection with opthalmological treatments.:
Expert:  Dr. Dan B. replied 7 years ago.

I do not know of a study which has been done which gives probabilities for such an adverse event; this is likely because it is not a common adverse event and happens in less than 10% of patients. I can certainly keep looking for such a percentage, but as of now, I know of no probability stated in safety trials or reports in the literature, currently.

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