Thank you for your reply.
All three of the medications (especially with bupropion and trazodone) can cause cornea tear film
disturbance which can in turn cause the irritation
of the cornea nerve and hence intermittent eye pain, with the left eye been more sensitive than the right eye. The regular use of preservative free tear drop (such as Refresh Plus or Genteal drop) 2-4 times a daily should reduce the dry eye
effect of these medications (especially the trazodone and bupronion) on the cornea.
Another possibility is to follow up with your eye doctor to check for astigmatic refractive error in the left eye that is causing you to restrain more to focus - even though you are able to see 20/20, the presence of astigmatism can make your left eye muscles
work harder to focus with intermittent eye pain. Finally, there are instances when tension and stress can induce what is known as ocular migraine
(with or without any headache or visual changes), except for intermittent eye pain. However, it is probably unlikely in your case.
In addition to using the preseverative tear drop, I would suggest that you use Zaditor (OTC) topical analgesic twice daily in the affected eye as needed. If after these measures (tears and zaditor) the symptoms continues after 2 weeks, I would encourage you to follow-up with your eye doctor for closer evaluation, especially checking for astigmatism and difference in the refractive errors between the two eyes.
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