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Dr. D. Love
Dr. D. Love, Doctor
Category: Endocrinology
Satisfied Customers: 18671
Experience:  Family Physician for 10 years; Hospital Medical Director for 10 years.
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I recently had a blood test for IGF-I and IGF-II. I am

Customer Question

I recently had a blood test for IGF-I and IGF-II. I am alarmed at my results - IGF-I came back at 418 ng/mL and IGF-II at 806 ng/mL. My doctor seems nonplussed - is this something I can safely forget about, or should I press on for more answers?
Submitted: 2 years ago.
Category: Endocrinology
Expert:  Dr. D. Love replied 2 years ago.
Hello from JustAnswer.
What was the reason that these labs were checked?
What symptoms are you having?
Customer: replied 2 years ago.
I am not 100% sure why they were checked. I have PCOS and Hashimoto's thyroiditis, and also have high DHEA levels. My symptoms are mainly fatigue, heart palpitations, headaches
Expert:  Dr. D. Love replied 2 years ago.
Your doctor was likely looking for evidence of deficiency.
Generally speaking, an elevated level of IGF-I or IGF-II are not worrisome if there are no symptoms that could be related to an increased level. The symptoms that you describe are not worrisome for a primary condition causing elevated levels, such as acromegaly, a condition of the pituitary gland that causes increased release of growth hormone. They also may be elevated associated with diseases of certain organs, such as the liver or pancreas, but there would usually be other evidence of liver disease.
Of course, we typically do not check these labs unless there are symtom that can cause abnormal levels, so your doctor was likely concerned that the levels were too low.
It would be appropriate to ask your doctor why the labs were checked when you next see your doctor.
If I can provide any clarification, please let me know.
Customer: replied 2 years ago.
Thank you. I have read that in cases like acromegaly, something like a pituitary tumor could cause elevated levels of growth hormones for years before more serious symptoms occur. Would it be worth it at this point to want to rule out a pituitary tumor?
Expert:  Dr. D. Love replied 2 years ago.
It may be years before serious symptoms occur, but there would usually be changes in growth that would be apparent on exam. So, we usually do not order an imaging test of the pituitary if there are no symptoms or findings on exam.