They are a little hard to enforce but not too bad as long as they are reasonable and you definitely need an NDA if yo uhave trade secrets so you want to get wit a local lawyer that does Employment Law and have them draft it.
You first need to find out what is going on with her health and her child's health because you don't want to be accused of violating the FMLA or the ADA.
However, you can likely prevent the taking of customer lists, revelation of trad secrets, etc. through an injunction. Injunctions are extremely difficult so you need a lawyer to assist you (and if you're a corporation you are required to have a lawyer).
The steps to an injunction are:
1) An Application for TRO (Temporary Restraining Order) is filed along with supporting evidence such as affidavits. Usually the Application for Injunction is made at the same time. The TRO is a temporary measure and is not absolutely required before you get an injunction.
2) An Ex Parte (without the other side present) Hearing is conducted and the judge either issues the TRO or denies it. If the TRO is issued the judge orders a bond set in a sufficient amount to compensate the other side for any damages accumulated while the TRO is in place if the applicant fails to prove their right to an injunction.
3) A hearing on the TRO is set.
4) The TRO and notice of Hearing is served on the defendant.
5) The defendant should immediately begin following the judge's orders.
6) The TRO hearing is held and each side has an opportunity to present evidence and question witnesses.
7) The judge makes the decision on whether to convert the TRO to a Temporary Injunction or not.
8) If the TRO is converted to a Temporary Injunction then the judge sets a new bond to be in place.
9) Discovery is conducted by both sides.
10) A request for hearing date is made on the matter of converting the Temporary Injunction into a Permanent Injunction.
11) The hearing/trial is held on the Permanent Injunction and the judge issues a ruling.
These are what are known as extraordinary remedies and the procedural rules for these as well as the case law are EXTREMELY specific and difficult. If ANY mistakes are made the judge has no choice but to deny the relief and will not likely reconsider it in the future.
Just as an example, getting injunctive relief, both temporary and permanent, requires that evidence be offered of:
1) An immediate need,
2) Which, if not granted, will result in irreparable harm,
3) With no adequate remedy at law, and
4) (on temporary order) The person requesting the injunction is likely to succeed at a full trial on the merits.
If evidence is not offered to meet these four requirements, in a manner that the judge knows this is what the evidence shows, then the petition will be denied.
There are more requirements than this depending on the exact facts of the case but it is very, very easy to mess up one of these and end up having to pay damages to the other side just because your paperwork wasn't done properly.
The injunction is the only real answer to your issues although you can sue her for damages. That will be harder to prove and without a NDA I'm not sure you can get there without putting an injunction in place.
I really can't tell you how to structure a conversation about this because it woudl depend on exactly what was said. You may even want to turn it over to the lawyer and let them handle it all. They will know how to draft letters, emails, etc. in such a way that if you have to sue then the letters will be admissible in court and work in your favor.
Although there is not a NDA in place you can still sue for and possibly get an injuncion