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He swallowed my ambian pills (not sure how many) hr is

Customer Question
He swallowed my ambian...

He swallowed my ambian pills (not sure how many) hr is stumbling around and throwing up and pooping

Veterinarian's Assistant: I'm sorry to hear that. This sounds like it might be serious. I'll let the Veterinarian know what's going on ASAP. Is there anything else the Veterinarian should be aware of about the dog?

No just the bottle of ils that fell to the floor he keeps going into corners

Submitted: 10 months ago.Category: Dog Veterinary
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Answered in 4 hours by:
10/5/2017
Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 10 months ago
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 35,473
Experience: University of California at Davis graduate veterinarian with 45 years of experience
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You're speaking to Dr. Michael Salkin. Welcome to JustAnswer. I'm currently typing up my reply. Please be patient. This may take a few minutes.

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Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 10 months ago

I'm sorry that your question wasn't answered in a timely manner. Please let me know if you still need help. May I have an update on your dog, please?

Ambian toxicity can be seen at 0.05 mg per pound of body weight but this is unpredicatable with that drug. Symptoms are usually mild to moderate but can include the following:

Severe sedation

Severe agitation

Hyperactivity

Aggression

Panting

Vomiting

Diarrhea

Drooling

Tremors

Hyperthermia

Walking drunk

Respiratory or cardiovascular depression

Here’s a thorough review of this intoxication:

J Vet Intern Med. 2002 Mar-Apr;16(2):208-10.

Clinical syndrome associated with zolpidem ingestion in dogs: 33 cases (January 1998-July 2000).

Richardson JA, Gwaltney-Brant SM, Albretsen JC, Khan SA, Porter JA.

Source: ASPCA Animal Poison Control Center, Urbana, IL, USA.***@******.***

Abstract

Zolpidem is a nonbenzodiazepine hypnotic of the imidazopyridine class that is used to treat insomnia in humans. Zolpidem binds selectively to the benzodiazepine omega-1 receptor and increases the frequency of chloride channel opening, which results in inhibition of neuronal excitation. A retrospective study was conducted of zolpidem ingestion in dogs that were reported to the ASPCA Animal Poison Control Center (APCC) between January 1998 and July 2000. Data analysis included amount ingested, clinical effects, and time of onset of signs. Thirty-three reports of zolpidem ingestion in dogs (ranging in age from 5 months to 16 years) were evaluated. Approximate ingested dosages ranged from 0.24 to 21 mg/kg. Clinical signs reported included ataxia (18 dogs; 54.5%), hyperactivity (10 dogs; 30.3%), vomiting (7 dogs; 21.2%), and lethargy (5 dogs; 15.2%), as well as panting, disorientation, nonspecific behavior disorder, and hypersalivation (4 dogs each sign; 12.1%). Other signs reported include tachycardia, tremors, apprehension, vocalization, hypersalivation, weakness, and hyperesthesia. In 85% percent of reports, clinical signs developed within 1 hour and usually resolved within 12 hours. Although central nervous system (CNS) depression is reported as a primary effect of zolpidem in humans and would also be expected in dogs, information obtained from this study indicates that some dogs may exhibit a paradoxical excitation reaction. This effect appears to vary among individual dogs

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