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Hi, i`m Richard, a Veterinarian from the UK. Hopefully I can help today.
These medications are used very commonly to treat heart conditions and I have never knowingly seen a seizure as a result of the medication. The event you saw may have been due to a cardiac event if his heart is really struggling?
In advanced cases we often need to start medication on loading doses to try and get the desired effect as quickly as possible. For the drugs you have been prescribed I generally dose new patients at 1-2mg/kg lasix twice daily (so roughly 15-30mg for Charlie Brown), Vetmedin 0.2-0.3mg/kg (so approx 3-4.5mg for Charlie Brown TWICE daily rather than 4 times daily) and enalapril I use a dose of 0.5-1mg/kg twice daily (so approx 7.5 to 15mg twice daily for your dog. I do not know personally of any benefit from giving the enalapril or vetmedin more frequently than every 12 hours.