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Rebecca, Dog Veterinarian
Category: Dog Veterinary
Satisfied Customers: 15586
Experience:  More than 30 years of companion animal practice.
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High liver enzymes but normal function enzymes as per

Customer Question

High liver enzymes but normal function enzymes as per bloodwork
JA: I'll do all I can to help. What seems to be the problem with the dog?
Customer: Vomited heavily the other night and was unable to get up after losing balance and seemed very weak and disoriented.
JA: This sounds like it might be serious. I'll let the Veterinarian know what's going on ASAP. Is there anything else the Veterinarian should be aware of about the dog?
Customer: She does have weak hind quarters and rear leg muscle atrophy.Have seen local vet and givingDenamarin to boost glutathione levels and will recheck livers in 1 week
Submitted: 2 months ago.
Category: Dog Veterinary
Expert:  Rebecca replied 2 months ago.

Thank you for using Just Answer. My name is Rebecca; I am a veterinarian. Please give me a moment to type my answer.

Expert:  Rebecca replied 2 months ago.

I am sorry to hear your dog has high liver enzymes. Do you have a copy of the blood test you can post here?

I see she is taking Denamarin, a good supplement to try to reduce liver enzymes. Is she on any other medication?

Usually with high liver enzymes, I next do an ultrasound of the liver, in hopes of getting a needle biopsy guided by ultrasound. Then you have a diagnosis of whether is is a liver infection, or inflammation, or (sadly in the case of my own dog with high liver enzymes) liver cancer. Once you have a diagnosis, you know the best treatment.

If she is vomiting you might consider Pepcid or Prilosec; how much does she weigh?

Steroids, antibiotics, and/or a liver medication called ursodiol might be helpful.

Please let me know if you have any more questions.

Customer: replied 2 months ago.
I don't have a copy of the labs, but my understanding is the parameters for liver function were ok .The other enzymes were elevated. She had been on Rimadyl for a year or more and my vet switched her to Galiprant 5weeks ago, but no liver tests had been done at that time. Local vet I saw did recommend ultrasound if test in 1 week still shows elevation in liver. The thing is though , my dog is 13-14 years old ,not sure exactly. She doesn't have a lot of time left even if she was healthy.More of a quality of life thing I think at this point. She is a pit bull lab mix and about 75 lbs. Have had her about 5 years ,had been in and out of shelters so I want to do the best for her.
Expert:  Rebecca replied 2 months ago.

I just would be interested to see how high the liver enzymes were.

Galliprant is supposed to be a safer anti inflammatory with liver disease than Rimadyl.

I am sorry but I can't make calls for the website; that offer did not come from me!

Expert:  Rebecca replied 2 months ago.

I would still consider the ultrasound if she were mine (my dog was 13 when she developed high liver enzymes). That is the best way to get a diagnosis, and getting a diagnosis is the way to know what treatment is best.

If an ultrasound is not possible, then I usually start these dogs on a combination of Galliprant or prednisone, antibiotics, ursodiol, Denamarin, and vitamin K1. Basically, I treat for every possible treatable liver disease I can.

Please let me know if this is helpful and what other questions I can answer. If this is helpful, kindly consider rating my answer so the website knows I am assisting you!

Expert:  Rebecca replied 2 months ago.
I'm just following up on our conversation about your pet. How is everything going?
Expert:  Rebecca replied 2 months ago.

I have not heard back from you. How is she doing? Was my answer helpful and can I answer anything else?