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Hi. My name is***** Sorry no one has helped you out prior to my coming on line now. As far as the female Weim with the swollen right thigh, the best initial thing to have done is a physical exam with your vet and most likely x-rays of that leg. They may also present the recommendation to do some blood work and chest x-rays based on what their initial findings are. As far as biopsy of this area and that causing spread of a cancer, unfortunately if it is cancer, it will follow the spreading principles with or without biopsy of it. A biopsy procedure won't cause it to spread quicker. The swollen leg could be due to cancer but it could also be due to some other pressure on the lymphatic / vascular drainage of that leg.