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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 30381
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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My 65 pound dog just ate a bupropion xl 150 mg pill, Seraph

Customer Question

My 65 pound dog just ate a bupropion xl 150 mg pill
JA: I'm sorry to hear that. The Expert will know if the dog will be able to digest that. What is the dog's name and age?
Customer: Seraph 18 months
JA: What is the dog's name?
Customer: Seraph
JA: Is there anything else important you think the Veterinarian should know about the dog?
Customer: No
Submitted: 2 months ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 2 months ago.

You're speaking to Dr. Michael Salkin. Welcome to JustAnswer. I'm currently typing up my reply. Please be patient. This may take a few minutes.

Expert:  Dr. Michael Salkin replied 2 months ago.

Buproprion is quickly absorbed in dogs and peak plasma concentrations are reached in 26 to 32 minutes. The half-life of bupropion in
dogs is relatively short at 1.73 hours. After an overdose, tremors and seizures can be seen within one to four
hours; however, signs may be delayed with extended-release products. Clinical signs of bupropion overdose include
vomiting, dyspnea, salivation, ataxia, seizures, arrhythmias, tremors, and hypotension. Depression can occur at 10
mg/kg orally (ASPCA APCC Database: Unpublished data, 2000). Seraph ingested just 5 mg/kg and so symptoms are expected to be mild. I would induce emesis, however, with 45 mL of 3% hydrogen peroxide given with a small poultry baster between her cheek teeth and cheek. She should vomit within 15 minutes. If not, please repeat the same dose. Please respond with further questions or concerns if you wish.