Hello My dog was diagnosed with grade 2 mast cell tumor Can i send u the report and u give me a little more information HfSTORY. DorsaL perianal mass.
GROSS DESCRIPTION. 4 cm skin ellipse with 2.5.cm ulcerated intradermal lesion.
HISTOPATHOLOGY. Multiple large sections of this lesj-on were examined revealinE
a poorly demarcated and unencapsulated mass with surface ulceration. The lesion
is dominated by mast cells forming loose clusters and sheets accompanied by
extensiwe central necrosis. Mast ce1ls are accompanied by numerous eosinophils
and the tissue is congested and oedematous. Mast ce11s raveal polygonal
outlines with granular cytopJ-asm and rounded to slightly oval nuclei containing
fine chromatin and basophilic nucleoli. There is some cel-l-ul-ar and nuclear
variation with scattered necrosis and miJ.d cel-1u1ar and nuclear atlpia. The
mitotic index is less than 2/10 high power fields. Tumour ceJ.J-s are apparent at
the deep and deep lateral margins.
DIAGNOSIS. Mast ceII tumour grade 2 (Ki-upel J-ow-grade) .
COMMENT. Mast ceLl tumours are conmon, infiltrative dermal- neoplasms in dogs
and all are potential-J-y malignant and have the potential for distant and
widespread metastasis. Grade 2 mast ce11 tumours are intermediate grade
neoplasms with a greater potential for invasion, recurrence and metastasie.
Older reports indicate that approximately 45t of dogs affected with Grade 2
lesions will die as a result of metastasis or inoperable recurrence if left
untreated. Some grade 2 mast ce11 tumours can be cured with wide-margined
The Kiupe1 grading system is a 2-tier grading system of either high-grade or
low-grade to clearly separate benign and malignant lesion. Criteria for a high
grade lesion include 7 or more mitotic figures per 10 high power fieldsi 3 or
more multinucleated ce1ls (3 or more nuclei) /10 HPF; 3 or more bizarre nuclei
per 10 HPF or karyomegaly (10* of nuclei vary by 2 fold or more). Using this
novel grading system high grade lesions were determined to have a median
survival time of (4 months and low grade lesions were shown to have median
survival times of )2 years. Kiupel, M et a1. Veterinary Pathology 2011 48:1
FINAI REPORT: 4/05/2017
VETPATH Laboratory Services
Page 1 of 2
JA: I'm sorry to hear that. Some lumps are serious and some aren't. Let's see what the Veterinarian has to say. What is the dog's name?
JA: Is there anything else important you think the Veterinarian should know about your dog?
Customer: Hes 6 years old hes a bullmastiff
, staffy, boxer