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Ask Dr. Meghan Denney Your Own Question
Dr. Meghan Denney
Dr. Meghan Denney, Dog Veterinarian
Category: Dog Veterinary
Satisfied Customers: 1387
Experience:  Veterinarian at Kingsland Blvd Animal Clinic
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My dog was diagnosed with grade 2 mast cell tumor Can i send

Customer Question

Hello My dog was diagnosed with grade 2 mast cell tumor Can i send u the report and u give me a little more information HfSTORY. DorsaL perianal mass.
GROSS DESCRIPTION. 4 cm skin ellipse with 2.5.cm ulcerated intradermal lesion.
HISTOPATHOLOGY. Multiple large sections of this lesj-on were examined revealinE
a poorly demarcated and unencapsulated mass with surface ulceration. The lesion
is dominated by mast cells forming loose clusters and sheets accompanied by
extensiwe central necrosis. Mast ce1ls are accompanied by numerous eosinophils
and the tissue is congested and oedematous. Mast ce11s raveal polygonal
outlines with granular cytopJ-asm and rounded to slightly oval nuclei containing
fine chromatin and basophilic nucleoli. There is some cel-l-ul-ar and nuclear
variation with scattered necrosis and miJ.d cel-1u1ar and nuclear atlpia. The
mitotic index is less than 2/10 high power fields. Tumour ceJ.J-s are apparent at
the deep and deep lateral margins.
DIAGNOSIS. Mast ceII tumour grade 2 (Ki-upel J-ow-grade) .
COMMENT. Mast ceLl tumours are conmon, infiltrative dermal- neoplasms in dogs
and all are potential-J-y malignant and have the potential for distant and
widespread metastasis. Grade 2 mast ce11 tumours are intermediate grade
neoplasms with a greater potential for invasion, recurrence and metastasie.
Older reports indicate that approximately 45t of dogs affected with Grade 2
lesions will die as a result of metastasis or inoperable recurrence if left
untreated. Some grade 2 mast ce11 tumours can be cured with wide-margined
excision alone.
The Kiupe1 grading system is a 2-tier grading system of either high-grade or
low-grade to clearly separate benign and malignant lesion. Criteria for a high
grade lesion include 7 or more mitotic figures per 10 high power fieldsi 3 or
more multinucleated ce1ls (3 or more nuclei) /10 HPF; 3 or more bizarre nuclei
per 10 HPF or karyomegaly (10* of nuclei vary by 2 fold or more). Using this
novel grading system high grade lesions were determined to have a median
survival time of (4 months and low grade lesions were shown to have median
survival times of )2 years. Kiupel, M et a1. Veterinary Pathology 2011 48:1
147-155
FINAI REPORT: 4/05/2017
VETPATH Laboratory Services
Page 1 of 2
JA: I'm sorry to hear that. Some lumps are serious and some aren't. Let's see what the Veterinarian has to say. What is the dog's name?
Customer: Socks
JA: Is there anything else important you think the Veterinarian should know about your dog?
Customer: Hes 6 years old hes a bullmastiff, staffy, boxer mix
Submitted: 2 months ago.
Category: Dog Veterinary
Customer: replied 2 months ago.
Also my other dog whos a sharpei cross has been licking and nibbling her feet alot n shes getting little sores do you have any idea why? She doesnt have fleas and she gets washed quitr regularly
Customer: replied 2 months ago.
how long do u think he has? And when should i know when to put him down? And how aggressive is it?
Customer: replied 2 months ago.
That picture was of my sharpei x sores. Thankyou
Expert:  Dr. Meghan Denney replied 2 months ago.

Hi I am Dr. Denney. I am currently reviewing your post now. Please give me 5-10 minutes to type my response after I have read through all the information . Thank you for trusting us with your question.

Expert:  Dr. Meghan Denney replied 2 months ago.

OK I need to ask a couple questions about the mass that was removed. I cannot see if they got clear margins or not. Did your veterinarian remove the whole tumor as far as they know?

How long was the mass present before it was removed ?

Has your dog had any other imaging done to check for metastasis : chest X-rays or an abdominal ultrasound ?hat information will help me give you average survival times.

There is also the option of going and seeing an oncologist and starting some low grade oral chemo therapy. Palladia has had great results in lengthening survival time. It is specifically used for mast cell tumors. Now chemo in animals is completely different than in humans as we are going for quality of life and do not use the high dosing that is used in humans so we do not see near the number of side effects in animals that we do in humans. Chemo can sound really scary but in animals it is a whole different thing than in humans.

With your other dog it could be allergies and even 1 or 2 flea bites can cause an allergy so I would recommend getting her on flea prevention ( also fleas only spend 20% of their lives on the pet and 8-% is off in the environment so it is actually quite rare for us to see a flea on a dog unless there is a heavy infestation). You can see about trying a medication called apoquel for itching allergies in dogs once you have talked with your veterinarian and they have made sure there is no secondary infection going on that is causing the itching cycle to continue. You can try epsom salt soaks to help some of the inflammation on the paws soaked for 5-7 minutes 2x a day.