I am researching other holistic therapies we can use in conjunction with the antibiotics
Treatment with forskolin, the main active ingredient in the Asiatic herb Coleus forskohlii, has been shown to increase cAMP levels and reduce the level of intracellular bacteria in the bladders of infected mice, which is thought to occur by stimulating the exocytosis of E. coli-containing vesicles.11 Therefore, in theory, administration of this dried herb could be beneficial in certain cases of recurrent E. coli UTIs that involve a nidus of infection in the bladder wall where antimicrobial therapy may have inadequate penetration.12 Potential side effects to consider are that components of Coleus forskohlii reportedly cause vasodilation, are positive inotropes, and decrease intraocular pressure.13 Although no clinical trials are available to provide information on efficacy, dose, or safety, this herb has been used anecdotally in veterinary medicine, in combination with appropriate antimicrobial therapy, for control of recurrent UTIs.
Methenamine. (100 mg 2x a day )
Methenamine is a urinary antiseptic that is hydrolyzed to formaldehyde and ammonia in acidic environments (pH < 5.5) and has bactericidal activity against E. coli and a variety of other microbes, making it useful to help treat or prevent recurrence of UTIs. It is available as a salt with either mandelic acid or hippuric acid, which act to acidify the urine; additional urine acidifiers may be needed as well. Although this nutraceutical has been used for years in veterinary medicine, studies regarding safety, efficacy, and appropriate dosing for veterinary patients are lacking. Gastrointestinal upset is a reported side effect, and methenamine should be avoided in patients with diseases associated with metabolic acidosis, such as chronic kidney disease. Methenamine is not well tolerated by cats.