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I will be happy to answer any questions about Bruce Wayne, I love his name! Has your treating vet performed any diagnostic testing?
Yes I did just take a look at the images, thank you for sending them. Was the bump that was biopsied in a similar location? Did it look at all like these new bumps? Do you live in an area where there are any stickers or foxtails that Bruce Wayne may walk through? Does he lick at these sores?
It sounds a little like that these infections could be started by material on the ground (stickers, grass) penetrating the skin and causing an infection. It is common for dogs to step on stickers and sometimes a piece of the sticker will get stuck, the bodies response is to try to push it out, often resulting in an ulcerated wound on the dorsal surface of the webbing between the toes. There are other potential causes for bumps like this e.g. pododermatitis that may be related to environmental or food allergy.
Having said that it is not possible for any veterinary to confirm the cause of a bump/swelling without diagnostic testing. Also golden retrievers are a breed that can develop tumors with increased incidence compared to other breeds. There are various types of ways to test bumps such as these...a biopsy usually involves surgically removing a small piece of tissue and submitting it for histopathology. This is the best type of test but is more invasive. Another option is to perform a needle aspirate (sometimes called a needly biopsy), this technique involves using a needle to draw out some cells and submitting it for cytology - examination of cells. This test is often less invasive and usually more affordable.
I suggest that you discuss these testing options with you vet and make a plan as to when to start with one of the tests, for example your vet might suggest a timeframe to monitor for response to antibiotics, then if there is not a favorable response then plan to do one of the tests. Please let me know if you have any other questions. Kind regards, ***** *****