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Ask Drhollowayvet Your Own Question
Category: Dog Veterinary
Satisfied Customers: 882
Experience:  Relief Veterinarian at Aloha Animal Hospital
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My 61 pound pit mix is on chloramphenical, 500mg, 3x/day..

Customer Question

My 61 pound pit mix is on chloramphenical, 500mg, 3x/day.. This dosage is the result of 2 skin cultures by our Vet. Although I also give a probiotic with the meds the dog seems to have lost her appetitie, which is problemactic because she should be taking the drug with food or at least after having eaten. The vet has given her anti-nausea injection but that does not seem to help. The dog has lost 6lbs in 2 weeks from not eating. No matter if I tempt her with treats or chicken or burger or hotdog, she will not eat.
JA: I'm sorry to hear that. The Veterinarian will know if the dog will be able to digest that. What is the dog's name?
Customer: Sable. She has not had any vomiting or diahrea.
JA: Is there anything else the Veterinarian should be aware of about Sable?
Customer: The chrloramphenical seems to have lessened her severe itching and reduced hair loss significantly.
Submitted: 10 months ago.
Category: Dog Veterinary
Expert:  Drhollowayvet replied 10 months ago.

Hello my name is***** but you can call me Dr. H, and I am a licensed veterinarian.

I understand that your pet Sable is having a very common side effect to the medication Chloramphenicol. This medication is notorious for causing GI distress (vomiting, diarrhea and anorexia) in pets that cannot be avoided no matter what you do.

The only option I can see at this point, especially if you vet has prescribed anti-nausea medication, is to ask your vet what other drugs is the infection susceptible to and trying those.

Based on a weight of 61lbs (27.7kg) and the dosage recommendation for Chloramphenicol @ 40-50mg/kg (around 1,000mg for your pets weight) every 8 hrs, it seems your pet is receiving below the recommended dosage anyway, so efficacy at this dosage is questionable.

Also if your pet has not already, I would encourage a topical medicated shampoo, preferably a Chlorhexidine based shampoo (Duoxo shampoo line has one available), to help manage the resistant bacteria topically.

- Dr. H

Expert:  Drhollowayvet replied 10 months ago.

As another alternative, I did have one case that did not have any other options drug wise and after consulting with a dermatologist on the case they suggested a very diluted bleach topical treatment. It was somewhere around 23:1 (water: bleach) dilutent that was used twice daily on the pet, left to air-dry outside for approx 15 minutes, and rinsed. Although I would not suggest you just go and do this with your pet, my point is that your vet may want to consult with a dermatologist on your pets case to see if this is an option for you. Typically the lab that your vet uses has consults that they can reference to (at no fee most of the time) for help with their tough cases like this one. Just a suggestion.

- Dr. H