i want to determine a reasonable dosing schedule and regimen for combination therapy for lyme and anaplasmosis. for humans, the newer approach is to go with combination therapy for chronic or refractory lyme. the international lyme and associated diseases society has this to say:http://www.ilads.org/lyme/ILADS_Guidelines.pdf26. Combination antibiotic treatment
Combination therapy with two or more antibiotics is now
increasingly used for refractory Lyme disease [11,41,45,46–49]
and has also been given as initial therapy for some chronic
This approach is already used for another tickborne illness,
babesiosis . Oral amoxicillin
, cefuroxime or (more
recently) cefdinir combined with a macrolide (azithromycin
or clarithromycin) are examples of combination regimens that
have proven successful in clinical practice, although controlled
clinical trials are lacking in persistent, recurrent and
refractory Lyme disease.
Combination therapy in patients with Lyme disease raises the
risk of adverse events. This risk must be weighed against the
improved response to combination therapy in Lyme disease
patients failing single agents [47–49].i want to determine which of these antibiotics are known to be safe in dogs and choose the combination and dosing to use. i am not interested in another round of single agent antibiotics. thank-you for your help.