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Hi I'm Dr. Gregg and I will try to help you tonight. Sorry Sophie is sick. How long ago was the diagnosis of pancreatitis made? Was there blood work run? Is Sophie eating? Does she have vomiting or diarrhea the last few days?
Since you have not answered I am assuming you are offline. Let me give you some ideas to consider. My first thought is if she has pancreatitis, that alone can cause weight loss, but sometimes results in pancreatic failure where she does not make enough of the enzymes to properly digest her food. Diarrhea is a sign of this.
Addison's disease can cause these symptoms as well. Do you know if they did an ACTH stimulus test?
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I am sorry to hear about your dog's distress and condition. Are you looking for help deciding about euthanasia or are you looking for treatment suggestions to discuss with your veterinarian?
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Ok, so pancreatitis can be a nasty disease, but is usually cyclical and does not typically cause weight loss over the long term. It is also tricky to diagnose and thus without knowing how the diagnosis was made, I cannot speak to its correctness. However, while it is a chronic condition, it tends to cause cyclic signs and "bouts" of illness as opposed to one long protracted episode. So, I am concerned that there is more going on than pancreatitis. Cancer comes to mind and I have had a few patients myself that were diagnosed with pancreatitis but because they didn't improve with standard treatment we investigated further and found pancreatic cancer. There are also other conditions that can mimic pancreatitis and will go undiagnosed without a thorough work up. As far as Addision's disease goes, the test is pretty straightforward. We test cortisol levels, give an injection and then measure the cortisol level afterward. If the level goes up we know that the dog is not Addisonian. If the level does not go up (or only goes up a little) then we know the the adrenal glands are not responding appropriately and the diagnosis is made. That being said, sometimes there can be confusing results and you have to look at the entire clinical picture to decide. There are two types of Addision's disease that dogs can get depending on which hormones are deficient. Since the adrenal glands produce glucocorticoid (cortisol) and aldosterone, deficiency of one or both of these may occur with different clinical signs. A dog that is only glucocorticoid deficient has normal electrolytes but still has other signs of Addison's disease such as excessive urination and thirst, GI distress, lethargy, and possibly low blood sugar. A dog that is deficient in aldosterone and cortisol has all of these plus electrolyte disturbances. Do you know if your dogs electrolytes are normal? Is she on a steroid currently? If so, did this resolve her clinical signs?