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Hello, this is Dr. Jess. There should be no negative interactions between the Trifexis, which is taken orally, and the collar you are describing. There are some dogs that experience irritation from the flea and tick collars, but most do fine with them. I would just keep a close eye on the skin around the neck for the first few days after placing the collar on Boone to be sure there isn't any topical irritation!