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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 30317
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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My dog swallowed 14 capsules of 22.3 mg each of Nexium

Customer Question

My dog swallowed 14 capsules of 22.3 mg each of Nexium containing esomeprazole magnesium delayed release. What do I need to do?
Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 1 year ago.

You're speaking to Dr. Michael Salkin. Welcome to JustAnswer. I'm currently typing up my reply.

Expert:  Dr. Michael Salkin replied 1 year ago.

The proton pump antacids such as esomeprazole and omeprazole (Prilosec) appear to be very well tolerated by dogs although there's little information on acute toxicity available. The LD50 (the dose that kills 50% of rats) is reportedly greater than 4 grams/kg (~1800 mg/lb) and humans have tolerated oral dosages of 360 mg/day without significant toxicity. It's too late to induce emesis in Carlton but I don't believe it's necessary to do so in any event. He ingested just 312 mg or 312 mg/50 lbs which is equivalent to ~ 6 mg/lb. Potentially, GI distress (anorexia, colic, nausea, vomiting, diarrhea, and flatulence) could arise but would be expected to be transient.

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