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Dr. B.
Dr. B., Veterinarian
Category: Dog Veterinary
Satisfied Customers: 20550
Experience:  Hello, I am a small animal veterinarian and am happy to discuss any concerns & questions you have on any species.
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I gave my 40 lb hound mix a double dose of Acepromazine and

Customer Question

Hello. I gave my 40 lb hound mix a double dose of Acepromazine and am now worrying about it. I gave him 50 mg. The recommended dose from vet was 25 mg. It's been about an hour and he isn't acting differently yet. Will he be OK? Should I take him to ER?
Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. B. replied 1 year ago.

Hello & welcome, I am Dr. B, a licensed veterinarian and I would like to help you with your wee one today.

Now if it has only been an hour, we will only just have this absorbing and a lack of signs isn't unexpected at this point. That said, what you have given is a very high dose, but not an overdose. So, it could cause severe sedation, lethargy and could affect his breathing/heart rate though should not be fatal.

Therefore, since it has been an hour and since this is twice what his vet advised for him and his health; we'd be best to err on the side of caution. To start, you can choose to induce vomiting at home. To do so, you can administer 3% hydrogen peroxide orally at a dose of 1ml per pound. (2 teaspoons per 10 pounds of body weight). You can give it via dropper, syringe, turkey baster – we just want to get it in. After giving this orally, move the abdomen around or get your wee one walking about to get things mixing. This should usually lead to vomiting. If it is unsuccessful after 10 minutes then it can be repeated twice more. And if we still have no vomiting, then you'd need to consider seeing your local vet (or ER vet) so that apomorhpine (a very strong injectable emetic) can be administered just get this out of the stomach and avoid any adverse issues.

As well or alternatively, you can also use activated charcoal at this stage. This is available over the counter from the pharmacy (ask for the high strength version in grams, not the one for gas since you will need a lot of these) and works by binding any remaining material in the stomach. For activated charcoal, we tend to give 1-4 grams per pound every 8 hrs. This can be mixed with food to be fed or with water to syringe feed (do note that it stains, so keep it away from white carpets/clothes). This will just limit how much is absorbed and reduce the intoxication risk here.

Overall, this is a very high dose but not an overdose. Still, as this drug is a sedative that has no antidote and could cause severe signs at this dosing level, we can use the above here to get some or all of the tablet back up and reduce the risk of any issue. Otherwise, if you cannot do this or if he were to show severe signs, we'd need him to his vet urgently for IV fluids to support his blood pressure and get this out of his system as quickly as we can.

Just in case you need a local emergency vet, you can check @ or via

Please take care,

Dr. B.


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Expert:  Dr. B. replied 1 year ago.


How is everything going with your wee one?

Dr. B.