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My Great Dane,has dry eye and diagnosis of auto immune

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disease of eye, has extreme...
My Great Dane,has dry eye and diagnosis of auto immune disease of eye, has extreme amount of mucous constantly. Is there more I can do, please?
Submitted: 1 year ago.Category: Dog Veterinary
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Answered in 1 minute by:
5/31/2016
Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 1 year ago
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 31,706
Experience: University of California at Davis graduate veterinarian with 45 years of experience
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Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 1 year ago

Yes, Rebecca, if cyclosporine 0.2% dosed every 8-12 hours isn't helpful you have four medical options...

1) Increase the concentration of cyclosporine to a 2% solution.

2) Switch to tacrolimus 0.02-0.03% ointment or aqueous suspension every 12 hours.

3) Consider pilocarpine at 1 drop of 2% pilocarpine/22 lbs of body weight on food every 12 hours until increased tearing or systemic side effects (e.g., vomiting, diarrhea, anorexia, salivation, bradycardia/slow heart rate) are seen. Pilocarpine is expected to be more effective in neurogenic dry eye rather than autoimmune dry eye.

4) Increase the frequency of dosing of an artificial tear; control secondary bacterial infection with a topical broad spectrum antibiotic such as bacitracin-neomycin-polymyxin antibiotic solution every 6-8 hours; consider anti-inflammatories if severe conjunctivitis and/or corneal vascularization/pigmentation are present such as dexamethasone 0.1% solution topically every 6-8 hours - only in the absence of corneal ulceration.

Consider parotic duct transposition if no response to lacrimostimulants is seen. Please respond with further questions or concerns if you wish.

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Dr. Michael Salkin
Dr. Michael Salkin
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