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Good Morning and welcome! I am Dr. Loretta, a licensed veterinarian and I am happy to answer your question.
It is suspitious that the discharge is coming only from the left nostril where the eye is having issues. This could be caused by a sinus infection or something inside the left nasal cavity. This would require an xray/Ultrasound to diagnose this condition. Since your gal has not responded to the antibiotics, it is time to take your gal to a specialist that can perform these diagnostics that will determine the actual cause and then she can be treated correctly. Until this is done, your vet is treating without any facts to support the treatment.
Does that make sense to you?
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Hi Linda. Sinus infections are very difficult to treat even with strong antibiotics so the fact that the Zpack did not resolve this, does not mean that this is not a sinus infection. These infections often need to be flushed and drained in order to resolve this. The discharge from your gal's eye could indicate a problem with the facial nerve caused by a an injury. The fact that there is only discharge from one nostril tells us that this nostril and left nasal cavity must be examined thoroughly to determine the cause. Linda, this may require a specialist with the right equipment.