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Welcome to Justanswer! I am Dr. Altman and happy to assist you both today!According to the veterinary formulary the dose is weight related but does not specify and I do tend to use a lower dose in smaller dogs as yours. One reference is:Mirtazapine is dosed at 3.75 to 30 mg per dog once daily depending on weight of the dog. For example: - Dogs less than 20 pounds = 3.75 mg once a day- Dogs approximately 21 - 50 pounds = 7.5 mg once a day- Dogs approximately 50 - 75 pounds = 15 mg once a day- Dogs greater than 75 pounds = 30 mg once a dayI agree with you that I would see if the 1/4 tablet daily will increase the appetite tonight and then consult with your veterinarian in the morning about your concerns. I always will start on the lowest possible dose and increase if warranted to stimulate the appetite. Better be safe than take risks that a higher dose might cause her to not feel even less like eatingPlease let me know how else I can assist you both tonight
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