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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 30398
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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Can dogs with Ehlriciosis and Babesiosis have large spleen,

Customer Question

Can dogs with Ehlriciosis and Babesiosis have large spleen, especially if they have had relapses? or is it likelyto be a hemangiosarcome? and can giving prednisolone 20mg BD in a 50kg Labrador retriever help increase his hemoglobin if he has sever anemia
JA: Thanks. Can you give me any more details about your issue?
Customer: i have a 6yr old labrador, 49 kg, who had three episodes of E.canis/Babesiosis which were treated partially due to wrong diagnosis he has now a large spleen with sever anemia, which has recovered to a large extent with prednisolne, iron, B12 and diet. can Prednisolone help if its a large spleen due to partially treated babesiosis
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Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 1 year ago.

Splenomegaly (enlarged spleen) is commonly seen with rickettsial diseases such as Ehrlichiosis as well as the hemoprotozoan parasite Babesia. Both infectious agents stimulate the immne system and the spleen is rich in immune-related cells. Hemangiosarcoma can arise in the spleen of a dog infected with these agents but can arise in any dog's spleen - usually at a median age of 8-10 years. Ultrasound is useful in clarifying why a spleen is enlarged. Ehrlichia and Babesia will cause a diffuse homogeneous change in the spleen while hemangiosarcoma usually forms discrete tumors.

Prednisone is the mainstay of therapy for an immune-mediated anemia particularly autoimmune hemolytic anemia (AIHA). It might be prescribed in refractory cases of rickettsial diseases or Babesia when an immune-mediated destruction of red blood cells is suspected. Prolonged immunosuppressive therapy with prednisone before specific antibabesial treatment can worsen outcome, however, and shouldn't be used in sick, hospitalized dogs.

Please respond with further questions or concerns if you wish.