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Hi, I can help you with your question today. I'm so sorry you are dealing with this. Chronically infected and painful ears can be so difficult.
I have one regime that sometimes will work to clear chronically infected ears. It does not always work, but I will use it as a last ditch effort before resorting to surgery.
When I first start the treatment, I use Synotic in the ears once daily for a week. I have my clients apply the drops without even attempting to clean the ears. The medication in Synotic is a strong anti-inflammatory, and I hope to reduce at least some of the pain and inflammation to make the remainder of the treatment more effective.
After that, we switch products to a combination of HydroPlus (Burow's solution and hydrocortisone) mixed with 1/2 of a 15gm tube of mupirocin ointment. The ointment does not dissolve well, and it takes a significant amount of effort to mix them together. Then, we fill the ear canals twice daily with the solution for at least 2 weeks before rechecking. If the ears are comfortable enough, they should be cleaned every other day with a commercial solution like Douxo Micellar cleaner.
This should all be done at the same time as the oral prednisone, and in those painful ears I will also add tramadol for additional pain control.
If this works, I still expect it to take at least 2-3 months before seeing the final results. Chronic ears may require chronic treatment also, perhaps twice weekly, to prevent full recurrence.
If this fails, then I recommend considering the option of surgery. Removing the diseased portion of the ear stops the pain. The dog will be deaf, but at this point she probably cannot hear anyway.
Please let me know if you have further questions. I am happy to continue until I provide the service that you seek. Here is my website if you need to reach me again: http://www.justanswer.com/veterinary/expert-drsusanfriend/