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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 29031
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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My Dog has un treated Cushings Syndrome. He also suffers

Customer Question

My Dog has un treated Cushings Syndrome. He also suffers from large bowel diahorrea. His Vet has proposed to treat him with Vetoryl which has a side effect of diahorrea.
If this happens and he can't take this medication What do we do. When do we consider euthanasia> My dog is a neutered Male 12yrs old Poodle Cavalier cross
Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 1 year ago.

Trilostane appears to be relatively well tolerated in dogs but up to 63 % of treated dogs can develop lethargy, mild electrolye abnormalities (low serum sodium, high serum potassium), vomiting, diarrhea, and inappetence during the first few days of therapy secondary to steroid withdrawal. These effects are usually relatively mild and self-limiting. Withholding the drug for a few days and then giving it every other day for a week may alleviate lethargy and vomiting. It's important that you go into this therapy with your eyes wide open. You can expect to spend in the low thousands the first year alone between visits, prescriptions, and testing. Treatment is life-long unless Ollie simply can't tolerate the drug (unusual) and then progressive symptoms of Cushing's usually prompts euthanasia. Some dogs can be nicely regulated within just a few weeks. Some, however, require months of dose adjustments and testing.

Please respond with further questions or concerns if you wish.