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Hi this is DRB and I would be happy to help you with this. Actually frontline can be applied every 2 weeks if needed without any toxicity at all. So if your dog is not feeling well then it is not the front-line,it is something else going on.When we have clients that have flea problems we use frontline every 2 weeks all the time. This is one of the nice things about this product. If she continues to act off, then I woudl suggest you take her in to an ER....but don't worry about the frontline. I hope this helps you. Sincerely, DRB
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Please let me know if you need additional assisatnce. Sincerely, DRB