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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 28538
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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My 15 to 20 lb dog ate 70 mg alendronate sodium is this life

Customer Question

my 15 to 20 lb dog ate 70 mg alendronate sodium is this life threatening
Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 1 year ago.

No lethality was observed in dogs receiving doses of up to 90 mg/lb. Observed adverse effects associated with overdoses included hypocalcemia (low serum calcium), hypophosphatemia (low serum phosphorus), and upper GI reactions (vomiting, mainly). The low calcium and phosphorus levels aren't likely to arise with a single overdose. A recently ingested overdose should be treated with orally administered antacids such as famotidine (Pepcid) at a dose of 0.25 mg/lb or omeprazole (Prilosec) at a dose of 20 mg; or milk to bind the drug and reduce absorption. Don't induce vomiting. Monitoring serum calcium and phosphorus levels are indicated if you see signs of weakness, tremors, or indeed, seizures which would represent severe hypocalcemia.

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