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Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 29828
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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Red discharge in corned of eye and around mouth. (Not blood)

Customer Question

red discharge in corned of eye and around mouth. (Not blood) I work at a Vet and we are at a loss to get rid of my 166lb. Great Danes yeast infection. He started with fungus on his pads, then yeasty ears, now the discharge from his eye and discoloration around his mouth. We have taken all carbs out of his diet, he gets plain yogurt twice a day, he is taking probios gel once a day, and we are using Zymox plus in his ears. I am wondering if Diflucan should be added? If yes, what dose?
Thank you
Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 1 year ago.

I'm sorry to hear of this with your Great Dane. If yeast (Malassezia) has been confirmed, the inexpensive ketoconazole dosed at 5 mg/lb once daily for a month should do nicely. You don't need to administer Diflucan (fluconazole) but if you prefer to do so, the dose is 4.55 mg/lb daily with food and treatment should continue until lesions resolve and follow-up skin cytology reveals no organisms (approximately 4 weeks). Bathing every 2-3 days in a shampoo containing 2% ketoconazole, 1% ketoconazole/2% chlorhexidine, 2% miconazole, 2% miconazole/2-4% chlorhexidine, or 1% selenium sulfide every 2-3 days should hasten remission. Please note that Malassezia overgrowth is almost always associated with an underlying cause such as atopy, food allergy, endocrinopathy, keratinization disorders, metabolic disease, or prolonged therapy with corticosteroids. It is not related to the amount of carbohydrates in his diet, plain yogurt doesn't replace the Malassezia with bacteria, and probiotics shouldn't be harmful but don't have a mechanism of action against Malassezia. Please respond with further questions or concerns if you wish.