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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 28504
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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My 12 week old yoykie pup has passed away, she was not

Customer Question

My 12 week old yoykie pup has passed away, she was not producing bone marrow, what could be a cause please,help
Submitted: 1 year ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 1 year ago.

My condolences for your loss of your Yorkie. Can you clarify for me, please, if she weren't producing red blood cells, white red blood cells, or both?

Customer: replied 1 year ago.
Both
Customer: replied 1 year ago.
She seemed fine when I got her then 12 days after she was not herself & had a 106 5 temp. Brought her to vet, next day still didn't seem herself, brought her to emergency hospital they tried everything but basically just supported her for 13 days nothing changes, antibiotics , sreroids etc .
Expert:  Dr. Michael Salkin replied 1 year ago.

Thank you. This is called a pancytopenia which can arise from primary bone marrow disease or disorders that affect the bone marrow. With diffuse marrow involvement, white blood cells are affected first, followed by platelets and finally red blood cells. Here are the specific diseases I see:

1) Aplastic anemia: Pancytopenia and a hypoplasic (under or incomplete development) marrow replaced by fat is seen. Most cases are idiopathic (unknown cause) but reported causes include infection (parvovirus, Ehrlichia), drug therapy such as antibiotics (trimethoprim-sulfa, chloramphenicol) and fenbendazole, and toxic ingestions (estrogens, e.g.).

2) Myelodysplasia: This is considered a preleukemic syndrome characterized by ineffective hematopoiesis (red blood cell production) resulting in a nonregenerative anemia and other cytopenias (thrombocytopenia/low blood platelets and leukopenia/low white blood cells). This disease can be primary or secondary. Primary syndromes probably arise from mutations in stem cells. Secondary syndromes are caused by neoplasia (cancer) or drug therapy.

3) Myelofibrosis: This causes bone marrow failure secondary to replacement of normal marrow elements with fibrous tissue. It can be a primary disorder or secondary to malignancies, immune-mediated hemolytic anemia, and congenital anemias (e.g., pyruvate kinase deficiency.

Bone marrow biopsy is necessary to clarify which of the above exists. If we can rule out drug toxicity, either a congenital (present at birth) and genetic disorder or idiopathic immune-mediated destruction of her bone marrow is most likely. Please continue our conversation if you wish.

Customer: replied 1 year ago.
She did not get into anything. How do we rule toxicity
Expert:  Dr. Michael Salkin replied 1 year ago.

If she didn't get into anything and wasn't administered any drugs prior to her being presented to her vet, you've ruled out a toxicity. Vaccinations, however, can cause a systemic inflammatory response syndrome (SSRI) which can affect the bone marrow and if she were administered fenbendazole as a wormer that drug can (rarely) cause bone marrow toxicity.

Expert:  Dr. Michael Salkin replied 1 year ago.
Hi,
I'm just following up on our conversation about your pet. How is everything going?
Dr. Michael Salkin