How JustAnswer Works:
  • Ask an Expert
    Experts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm.
  • Get a Professional Answer
    Via email, text message, or notification as you wait on our site. Ask follow up questions if you need to.
  • 100% Satisfaction Guarantee
    Rate the answer you receive.
Ask Dr. Gary Your Own Question
Dr. Gary
Dr. Gary, Dog Veterinarian
Category: Dog Veterinary
Satisfied Customers: 19798
Experience:  DVM, Emergency Veterinarian, BS (Physiology)
Type Your Dog Veterinary Question Here...
Dr. Gary is online now
A new question is answered every 9 seconds

My dog takes 64.8 mg of phenobarbital twice daily plus the

Customer Question

My dog takes 64.8 mg of phenobarbital twice daily plus the time release version of keppra. Her dose was just raised to 1500 mg twice daily from a month at 750mg twice daily. She is still having a seizure very 10-14 days, and cannot control hr bladder. What can I do, and how much damage is this causing?
Submitted: 2 years ago.
Category: Dog Veterinary
Expert:  Dr. Gary replied 2 years ago.

Hello. Thanks for the question.

I think part of the issue here is the timing of the meds. Keppra is a medication that has to be given every 8 hours. If you're off more than 30-40 minutes, you won't get good control. If you're giving it every 12 hours, it's really not going to be effective. If you're unable to give a medication every 8 hours, then you can't use Keppra. In that case, you should use Zonisamide. Zonisamide can be given every 12 hours and be effective.

I would also make sure you have Phenobarb blood levels run. If they are < 20, then the dose should be increased before adding a second line drug. If we're in the mid 20's or up around 30, then we add Zonisamide at twice daily or Keppra at 3 times daily. You may want to consult with a neurologist to get this better controlled.

I wouldn't worry about the other organs. Just monitor blood levels every 6 months to make sure they are ok. The more important issue is getting the seizure numbers down to < 6-8 per year.

I hope this helps, let me know if you have any other questions.

Customer: replied 2 years ago.
Thanks. That was helpful
Expert:  Dr. Gary replied 2 years ago.

You're welcome.