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Hi. Welcome to Just Answer. My name is***** and I've been a veterinarian for 15 years. Frontline is a product that is a different insecticide than what is in Seresto. It can be used at the same time as Seresto because of this. Seresto has pyrethrin in it so other products that have pyrethrins in them shouldn't be used at the same time. So there isn't a period of time where removing the collar is needed before applying Frontline. It can be used right away.