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Dr. B.
Dr. B., Veterinarian
Category: Dog Veterinary
Satisfied Customers: 21419
Experience:  Hello, I am a small animal veterinarian and am happy to discuss any concerns & questions you have on any species.
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My 5 month old labradoodle was started on cefpodoxime rash

Customer Question

Hi my 5 month old labradoodle was started on cefpodoxime for a rash he has on his belly. He has been taking it for 3 days and now has developed a dry hacking cough I've never heard before. What could it be?
Submitted: 2 years ago.
Category: Dog Veterinary
Expert:  Dr. B. replied 2 years ago.
Hello & welcome, I am Dr. B, a licensed veterinarian and I would like to help you with your wee one today.
Now I would first note that coughing is not a common adverse effect of this antibiotic. In fact, if we do have a dog that is sensitive to this medication, our most common signs we see are GI upset (appetite loss, vomiting, diarrhea).
That said, since dogs do tend to take tablets without drinking a glass of water to push them down as we do, it is possible that this medication has caused some mild throat irritation. Otherwise, we'd have to be a wee bit concerned that this may not be related to his current issues and that Bruce may have also picked up a kennel cough type infection (possibly from his vets) that is not responsive to the antibiotic being used for his skin. So, we do need to monitor this and tread with care.
With all this in mind, I would advise making sure that he is given his tablets either with his meal or in the middle (since we don't want to give it first thing and risk stomach upset too). Also to soothe his throat, you can give him a tablespoon of honey+glycerin cough syrup (without drugs in it) or even plain honey. Alternatively use Robitussin DM but you must take care not to use one with cold medication added to it. It will take some label reading, but do avoid any syrups with cold medications in (ie acetaminophen, paracetamol, ibuprofen or any human cold medications since many are toxic for dogs), you just want one to lubricate and soothe the throat. When using Robitussin DM, we tend to give 1 milligram per pound of their body weight every 8 hours. And all of these could help ease any mild irritation there.
Overall, this isn't a sign that we would readily expect from this antibiotic. Therefore, we'd want to err on the side of caution here. So, do use the above +/- soft foods to soothe his throat. But if he isn't settling, then to ring his vet as they may want to alter or add in a second antibiotic to tackle this as well.
I hope this information is helpful.
If you need any additional information, do not hesitate to ask!
All the best,
Dr. B.
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