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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 29004
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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6 pd dog ate 22 pd dog monthly triflexis treatment. Dog was

Customer Question

6 pd dog ate 22 pd dog monthly triflexis treatment . Dog was initially fine , this happened last pm. He grabbed dosage when larger dog spit it out. Now he is lethargic, won't eat. What should we do.
Submitted: 2 years ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 2 years ago.

Trifexis contains both spinosad and milbemycin. The amount of milbemycin for a 6lb dog in Trifexis is 2.3 mg. The amount of milbemycin recommended for a 22 lb dog is 9.3 mg but this drug is very well tolerated in dogs. In fact one study showed doses of 200X the recommended dose were well-tolerated. The spinosad in the 22 lb Trifexis is 4X that found in the 6 lb Trifexis. It, too, however is a very well-tolerated drug in dogs but is known to cause transient gastrointestinal distress - inappetence, vomiting and/or diarrhea - even at recommended doses. In one study 17X the recommended dose was tolerated.

There's no specific antidote to spinosad overdose but you should expect complete remission in Leonard within 36 hours of his inappropriate ingestion. Administering an over the counter antacid such as famotidine (Pepcid) at a dose of just 2.5 mg (1/4 of a 10 mg tablet) and repeated in 12 hours should afford Leonard some comfort. Fasting is acceptable but water should be available at all times. If drinking induces vomiting, please replace his water with ice cubes for him to lick. Please respond with further questions or concerns if you wish.

Expert:  Dr. Michael Salkin replied 2 years ago.
Hi Angela,
I'm just following up on our conversation about Leonard. How is everything going?
Dr. Michael Salkin