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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 29749
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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My 15 year old Doxie has just been diagnosed with cushings

Customer Question

Hi, My 15 year old Doxie has just been diagnosed with cushings disease and the vet wants to start him on Trilostane, I'm concerned about the side effects and all that I read about this drug.??? more details like his weight?? he is 23.lbs , a male,
Submitted: 2 years ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 2 years ago.
Aloha! You're speaking to Dr. Michael Salkin
I would be reticent about treating any 15 year old for Cushing's unless his symptoms were unacceptable. Please tell me what you're seeing at this time.
Trilostane appears to be relatively well tolerated in dogs but up to 63% of treated dogs can develop lethargy, mild electrolyte abnormalities, vomiting, diarrhea, and inappetence during the first few days of therapy secondary to steroid withdrawal. These effects are usually relatively mild and self-limiting. Withdrawing the drug for a few days and then giving it every other day for a week may alleviate lethargy and vomiting. It's important to note, too, that twice daily dosing at the low dose of 1.25 mg/lb divided/day is better tolerated and a more complete clinical recovery is seen. This dose is newer than originally recommended for this drug.
Expert:  Dr. Michael Salkin replied 2 years ago.
I'm just following up on our conversation about Oliver Abercrombie. How is everything going?
Dr. Michael Salkin