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I have a 16 y/o Brussels griffon. She has Cushings disease

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Hi Dr Michael. I have...
Hi Dr Michael. I have a 16 y/o Brussels griffon. She has Cushings disease and she's beng treated for that quite well with Vetoryl 10mg once per day. She has a level 4 heart murmur and my vet prescribed pemobendan and enalarpil which she nearly died from. I took to her to a cardiologist who confirmed her murmur but he did not think comtinung the heart meds was necessary. Fast forward 1 year and my vet recommended she go on Enalapril (again) to help w energy levels. I've been giving it to her for one month and I don't see any benefit. In fact, she has bouts of horrible diarrheah and lethargy. I decreased the dose 1/2 and she's a little better but still having diarrhea and lethargy. Can I stop giving her the enalapril immediatly without risking a dangerous side effect? The Cushings isanaged very well now so I do not suspect Cushings being responsible for any of these issues we are having. Money and time are not a factor. I will do whatever, I just feel likey vet is not listening to me
Submitted: 2 years ago.Category: Dog Veterinary
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Answered in 5 minutes by:
8/9/2015
Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 2 years ago
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 30,753
Experience: University of California at Davis graduate veterinarian with 45 years of experience
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Aloha! You're speaking to Dr. Michael Salkin
Yes, there's no need to taper enalapril but you have to promise that if stopping its administration doesn't correct her diarrhea and lethargy, that you pursue the cause of those symptoms. Enalapril can worsen kidney function and so it would be prudent to have a kidney diagnostic panel performed at this time. Worsening of kidney function can cause diarrhea and lethargy.
Please respond with further questions or concerns if you wish.
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Customer reply replied 2 years ago
Aloha Dr. Michael. Apologies for the spelling errors in my first question. Thai has extremely high liver values and decreased kidney function. This has been the case for the last 3 years. The diarrheah and lethargy have worsened since the enalapril. Perhaps the diarrheah from the enalalaril is causing some lethargy. At 16 y/o Im hesitant to do any invasive testing such as an ultrasound w liver sample like the vet suggested.
Customer reply replied 2 years ago
I'm hesitant because she becomes very out of sorts and stressed at the vet. And at 16, I don't feel right putting her body through treatment that could difficult for her body to handle.
Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 2 years ago
I understand. I'd be very conservative with Thai as well. I'd stop the enalapril. It may well have worsened already compromised kidneys. I can't imagine what would be gained by biopsying a 16 year old's liver under ultrasound guidance. It's time for good hospice care not intensive care.
Please continue our conversation if you wish.
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Customer reply replied 2 years ago
I agree. Thank you for your help
Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 2 years ago
You're quite welcome. I can't set a follow-up in this venue and so would appreciate your returning to our conversation with an update - even after rating - at a time of your choosing.
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Dr. Michael Salkin
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 30,753
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Experience: University of California at Davis graduate veterinarian with 45 years of experience

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