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Our dog cockapoo 10kilo has eaten 1 adenuric gout tablet 80mgHe

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Our dog cockapoo 10kilo has...
Our dog cockapoo 10kilo has eaten 1 adenuric gout tablet 80mg
He is fine and appearing no difference
Will he be ok?
Submitted: 2 years ago.Category: Dog Veterinary
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Answered in 2 hours by:
6/6/2015
Dog Veterinarian: Dr. Michael Salkin, Veterinarian replied 2 years ago
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 30,851
Experience: University of California at Davis graduate veterinarian with 45 years of experience
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Aloha! You're speaking to Dr. Michael Salkin
Yes, I expect so. There's a paucity of information concerning toxicity of febuxostat (Adenuric) in dogs but I did find this: "The in vitro and animal studies with febuxostat showed it was more potent than allopurinol in reducing serum urate levels without any major additional adverse effects (Tomlinson 2005)." This: "In anaesthetized dogs (10, 100 mg/kg intraduodenal) febuxostat had no effect on respiration rate, blood pressure, heart rate, left ventricular pressure, left ventricular contractility, femoral blood flow or ECG." And most important, this: "In Beagle-dogs no death was observed at doses up to 2000 mg/kg p.o., e.g. the highest non-lethal dose for febuxostat p.o. was 2000 mg/kg. Clinical signs were severe vomiting at all dose levels, prone position, lateral position, depression, decrease in locomotor activity, ptosis, decreased body surface temperature, salivation, loose stools. Beginning complete recovery of clinical signs was observed at post administration day 1."
Please respond with further questions or concerns if you wish.
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