Aloha! You're speaking to Dr. Michael Salkin
Yes, I expect so. There's a paucity of information concerning toxicity of febuxostat (Adenuric) in dogs but I did find this: "The in vitro and animal studies with febuxostat showed it was more potent than allopurinol in reducing serum urate levels without any major additional adverse effects (Tomlinson 2005)." This: "In anaesthetized dogs (10, 100 mg/kg intraduodenal) febuxostat had no effect on respiration rate, blood pressure, heart rate, left ventricular pressure, left ventricular contractility, femoral blood flow or ECG." And most important, this: "In Beagle
-dogs no death
was observed at doses up to 2000 mg/kg p.o., e.g. the highest non-lethal dose for febuxostat p.o. was 2000 mg/kg. Clinical signs were severe vomiting at all dose levels, prone position, lateral position, depression, decrease in locomotor activity, ptosis, decreased body surface temperature, salivation, loose stools. Beginning complete recovery of clinical signs was observed at post administration day 1."
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