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A person convicted of simple misdemeanor domestic violence faces a maximum of up to 6 months in jail and/or a fine up to $1,000, though if this is a first offense, a person who is convicted is more likely to get probation, which can include things like reporting to a probation officer, community service, and mandatory attendance at a domestic violence class. Also, even though it is a misdemeanor, a person convicted of this charge will loose their right to own a firearm. Even attempting to cause bodily injury is enough to sustain a conviction -thus raising a hand as if you were going to strike a person would be enough for a conviction.
It's a serious charge, and going into criminal court on any type of criminal charge bigger than a simple traffic ticket is foolish. It would be the equivelant of a person who has no experience flying planes getting into the cockpit of a 747 and trying to fly. Therefore, if your friend has not spoken with a lawyer yet, he should definitely do so before his first court appearance (many lawyers offer free or low cost consultations).
All that said, it's hard to predict the outcome of this case without knowing all the facts and circumstances and without seeing any evidence, such as police reports. Have I met clients who swear they never touched a person who were later convicted on the words of the accuser? Yes. The prosecutor has to prove guilt beyond a reasonable doubt, which is a high burden of proof, but it's not unheard of for an accuser's testimony to result in conviction.
There certainly are ways for a lawyer to fight it. If he did touch her in any way, self defense can be argued (e.g., he was just pushing her away, or grabbing her hands to avoid being hit). Sometimes a "victim" changes their mind and does not want to press charges, and then the attorney can get the victim to sign an affidavit to that effect. A lawyer may be able to negotiate with the prosecutor to drop the matter before it ever goes to trial due to the lack of witnesses and the fact that there were no injuries or medical reports. And, if it does go to trial, your friend's lawyer can attack both the accurer's testimony and question the officer as to the fact that no witnesses saw anything, the victim had no injuries, they were not taken to the hospital for treatment, etc.
If you would like any additional information or have more questions please don’t hesitate to ask.