I'm sorry Prrrrl is exhibiting these worrisome symptoms.
There is a condition called feline hyperesthesia, in which a cat's back may become very sensitive, twitch or 'ripple', and she will take off running all of a sudden, and try to lick or bite her back hip/sides, and/or tail, frantically. It's possible that this is what Prrrrl is experiencing, but the panting is of concern. Of course, if she continues to run, she could be tiring herself out and that's why she's panting.
She could have gotten bitten or stung by a spider or insect or even be having a reaction to fleas or mites (even though you can't see them).
If she doesn't want to be touched, it's because she's in pain, so there's not much you can do from home, not knowing what's causing her symptoms. It would be best to get her seen in person by a vet, asap, to get a definite diagnosis and treatment.
You can throw a big towel or blanket over her, from the back (including her head) and put her in her carrier to head to the vet or ER vet if your vet is not open, now.
I hope all will be well with Prrrrl, and please let me know how she's doing and what the vet's findings are. Thanks!
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