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Hello, I'm Dr. Deb and will do my best to help with this concern about Shadow.
It's not uncommon for cats with pulmonary edema or fluid surrounding their lungs to require increased doses of lasix to control them; the fact that she's done so well for as long as she has is almost short of a miracle. But she is a cat after all which likely explains it:)
Typically, the rule of thumb when it comes to lasix is to give the dose which effectively controls the patient's symptoms. Which basically means that if she's doing well with the tablets given once a week as opposed to every other week, then this is her new dose....or it could be given every 4-5 days, if that's what is required. Whatever is required is the dose she should be given if she were my patient.
There's always a risk, of course, if her kidneys aren't stable but this is one of those situations where we're trying to provide quality of life for as long as possible. The goal, for me at least, would be to provide her with reduced fluid in his lungs so that she can breath easier.
I hope this helps, Deb
I'm sorry that I've been off my computer and have just now seen your additional question.
I really can't explain why your vet has prescribed liquid and pills although every pet practices differently; this just isn't a protocol with which I'm familiar.
However, my response remains the same: her dosage amount is what best controls her symptoms, whatever that "amount" might be.
It's not that cats necessarily develop resistance, it's that the underlying disease process progresses which requires more drug to control it.
Eventually, her condition will catch up with her although it gives me no pleasure to say so:( But, it's still pretty amazing that she's doing so well.
Respiratory rates will vary throughout the day in cats and dogs and don't remain at a steady level. However, as you probably know, 20-30 breaths per minute is the norm for most cats at rest so hers are a little higher.
That's great that she's not showing any signs of distress but it's always a good idea to have these sort of patients rechecked on a regular basis.