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1) When did he last eat a normal meal? 2) Any vomiting or diarrhea? 3) Is he still drinking or nothing at all by mouth?
It sounds like his appetite is reduced and due to the antibiotic he's likely dealing with a GI upset. The most ideal approach would be to have him examined at the ER and treatment started for the suspect GI upset. In these cases, we can often keep a cat on the treatment they're taking and also treat the GI upset they're experiencing. Failing this, you can skip the antibiotic today and talk to your vet tomorrow when they open to see what course of action would be ideal. When possible, we avoid taking pets off of antibiotic courses unless necessary so as to not encourage antibiotic resistance in their bodies. That said, sometimes there is no choice.Keep encouraging him to eat, even if it's small amounts.
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