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Hello. Thanks for writing in. My name is***** and I would be happy to help you. With open, oozing sores, antihistamines and an anti-itch spray won't cut it. At the very least, she needs to be on an antibiotic. The problem still lies with finding the source of issue. It could be parasite related, a hormonal issue (i.e; Cushing's disease), a complicated bacterial infection (i.e.; Nocardia, Mycoplasmosis, Leprosy), an immune system problem (i.e.; pemphigus, drug reaction) or even cancer. Given the weight loss, I would be more concerned about an internal problem or a nasty infection. All of these issues have to be treated differently, and there isn't much you can do at home with over the counter stuff besides bathing in a chlorhexidine based shampoo daily. I would highly recommend getting her to your vet to get checked out and see what potential testing they need to run. At the vary least, I would see if they can prescribe some antibiotics. Please let me know if you have any other questions or concerns. Hope this helps.