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VS V6 is known for spark plug leads crossfiring etc.
You have said you have replaced the leads, how old are they now?
Did you fit the correct spark plugs, and not crack any?
Was it misfiring prior to changing the leads and plugs?
You probably have a faulty coil, there are 3 separate coils.
Did you find a faulty coil?
Two cylinders would be misfiring with one coil out.
Very common failure.