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I need to know more of the basic facts.
For example, is there any order or agreement about this?Also, are you saying the great grandfather and spouse adopted the children?
When the children were adopted was there any order made about who could have access to these children or was there agreement made about this?
Was the agreement in writing?
When is the last time your sister saw the children?
How often did you see the children before the adoption?
Your sister can apply to the court for an order for access. She will get this if she can show that what she is asking for is in the best interests of the children and it certainly sounds like it would be since she saw them almost every day.But a better first step would be for her to consult with a family lawyer who has dealt with issues such as those relating to grandparents' if possible and have that lawyer write the adoptive parents a letter essentially saying that your sister wants to resolve this amicably but if necessary she will obtain a court order as she believes strongly that the children are being harmed by being denied access to her.
It is likely they will agree as they will not want to be dragged into court and when they see a lawyer the lawyer will likely advise them to give your sister access so that they do not have to go to court where they will likely not succeed.