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Is the issue with the new radio the same as the reason you were replacing the old one?
with the radio pulled out, do you have power at both pins 15 and 16 (wires are both red with yellow tracer) These pins are powered from fuse B8 and C28. Check to make sure you have power at both of these fuses, they are powered by fuse A1
It sounds like you have another bad radio. Those wires should power up both the radio, and the SAFE display.
T16b/12 is your ground. The radio should be able to be turned on without the key on, and the key on activation is done through the BUS system, as long as the radio has power.