Ask a Vet and Get Your Veterinary Questions Answered.
I would suggest further characterization of her kidney problems. Most often, dogs and cats have chronic renal failure which is due to general loss of function over time. However, renal failure can also be caused acutely by infection diseases (ascending pyelonephritis or leptospirosis for example), toxins, select medications, etc.
I would consider a urine culture, leptospirosis titers, and an ultrasound to search for an underlying cause. Some conditions may be reversible with appropriate treatment.
However, if she does have chronic renal failure, it is not a good sign that she isn't responding to IV fluid therapy. At that point, I counsel my clients to monitor the pet's quality of life closely. When they stop eating, become withdrawn or depressed, I think it is time to consider humane euthanasia.
I hope this helps.
Please let me know if you have any further questions. If you are satisfied with my answer, please click on the green Accept button. Positive feedback is always appreciated. Thanks.