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Hi there, PSA is a glycoprotein produced by prostate epithelial cells. PSA levels may be elevated in men with prostate cancer because PSA production is increased and because tissue barriers between the prostate gland lumen and the capillary are disrupted, releasing more PSA into the serum. Studies have estimated that PSA elevations can precede clinical disease by 5 to 10 years or even longer. However, PSA is also elevated in a number of benign conditions, particularly benign prostatic hyperplasia (BPH) and prostatitis
Men with a PSA rate of change (PSA velocity) greater than 0.75 ng/mL/year were at increased risk of being diagnosed with prostate cancer, and therefore, you will need to have a biopsy with the urology physician to rule out prostate cancer
Therefore, the fact that you went from 1.5 to 3.7 into years means that your velocity was too high or that your PSA was increasing too fast. Normally, it should have only increased by .75 a year which means that your PSA this year should have only been around a maximum of three.
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