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Yes. He can take Tylenol. All medications that are designed to stop bladder spasms can affect his ability to void. This it's because the medication actually comes the bladder by slightly paralyzing it to stop the spasms. This can lead to difficulties with emptying the bladder. But not everyone will have problems emptying. I would recommend his doctor prescribe something like Detrol or Ditropan to help stop the spasms. Hope this helps.