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My mother is 80 years old and has stage 4 COPD. I am looking

My mother is 80 years old and has stage 4 COPD. I am looking to see what your opinion is on getting stem cell treatments for her COPD. Have you heard of any positive outcomes with this procedure and if so, do you know of any facilities in the state of NJ. I was in contace with a facility in Florida called the US Stem Cell Clinic and filled out the necessary forms and she was approved to undergo the procedure. I did not schedule the procedure because of the distance involved and did not think my mother would do well with the travel. I would appreciate any input you can give me. Thank you.

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khagihara

Post-Doctoral Degree

 
5,404 satisfied customers
Do y0u think stem cells treatment is effective ?

do y0u think stem cells treatment is effective for ataxia?

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Dr. Phil, MD

Internal Medicine Physician

Doctoral Degree

 
39,416 satisfied customers
This is a question regarding what is a biology term-

This is a question regarding what is a biology term- restoration. What exactly does this mean? I can not tell from reading about this. It seems mammals are capable of this in certain tissues like skin, and it says this means tissues are restored to their original quality, but is this exact restoration or complete restoration? So what does that term mean exactly, regarding mammal tissues? If you mention the role of stem cells in this it would clarify it even more...from what I know. What exactly, happens in restoration? Maybe the best kind of restoration where it is the best, ***** ***** scar tissue or incomplete restoration to compare.

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khagihara

Post-Doctoral Degree

 
5,404 satisfied customers
My husband had a stem cell transplant . He is about

My husband had a stem cell transplant for AML. He is about 175 days post transplant. He had diarrhea last week with nausea & loss of appetite. He had an esophageal & small colon scope which revealed he had CMV. He was taking valtrex & his nurse said the CMV penetrated the valtrex barrier. He's in the hospital getting IV antiviral drugs. What does this mean & why is this so dangerous for my husband.

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khagihara

Post-Doctoral Degree

 
5,404 satisfied customers
Dr. Phil,I had breast cancer 2 years ago and now have

Dr. Phil,I had breast cancer 2 years ago and now have DTC's in my bone marrow. Zometa is supposed to cure that in POST-menopausal women. Actually in 5-years post-menopausal women. So I had an oophrectomy in Fall 2014.I also have very very dense bones. Which is bad, because the zometa doesn't like osteoblasts. They may keep it from working.This is the article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053096/ It also mentions other things the zometa does (where I don't think the osteoblasts matter)--like discourage adhesion, angiogenesis, proliferation.But here are some excerpts. I am so afraid the zometa isn't going to work and the dtc's are going to spread:"Another possibility is that the bone microenvironment in estrogen-exposed women better supports thesurvival and expansion of disseminated tumor cells in the endosteal niche. This idea is supported by the findings that estrogen increases the number and activity of endosteal osteoblasts [22], which are critical mediators of stem cell dormancy and survival [23]; estrogen may thereby impede the ability of ZA to decrease disseminated tumor cells."Also: "Estrogen, acting through osteoblasts, could support a dormant tumor cell niche in bone, enabling disseminated cells to survive high intra-osseous ZA levels. ZA and estrogen could have antagonistic effects on cytokine stimulation of angiogenesis, on tumor-promoting or suppressing activation of macrophages, or on the mobilization and function of NK cells acting on tumors."Serioiusly, I have 99.99 percentile bone density. They don't know why.

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Dr. Phil, MD

Internal Medicine Physician

Doctoral Degree

 
39,416 satisfied customers
Dr. Phil,I take zometa to kill the dtc's in my bone

Dr. Phil,I take zometa to kill the dtc's in my bone marrow. But I have found an article that indicates it won't work, because I have very very dense bones (possibly from childhood fluoride pills).Read this--it says zometa doesn't work if there are osteoblasts:Another possibility is that the bone microenvironment in estrogen-exposed women better supports the survival and expansion of disseminated tumor cells in the endosteal niche. This idea is supported by the findings that estrogen increases the number and activity of endosteal osteoblasts [22], which are critical mediators of stem cell dormancy and survival [23]; estrogen may thereby impede the ability of ZA to decrease disseminated tumor cells.ANDThere is increasing evidence that ZA could affect survival of disseminated tumor cells, whose prevalence predicts local and distant relapse [14]. Both neoadjuvant and postchemotherapy administration of ZA (and other bisphosphonates) have been shown to decrease disseminated tumor cells in marrow compared with pretreatment levels [15,16], lowering the risk of metastatic spread from micrometastases. This occurrence could represent an anti-cancer effect. Interestingly, osteoclasts and osteoblasts have been implicated in the maintenance of dormant leukemic clones in the marrow [17], which may also be the case for breast cancer. Moreover, breast tumor cell viability in the endosteal niche has been shown to involve heterotypic notch/jagged interactions with osteoblasts similar to those used to regulate hematopoietic stem cell numbers [18,19]. ZA-mediated shifts in osteoclast and osteoblast function may therefore lead to changes in the microenvironment that undermine support for disseminated cancer cells.What do you think?

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khagihara

Post-Doctoral Degree

 
5,404 satisfied customers
Dr. Love,Read this, it is from that zometa/estrogen

Dr. Love,Read this, it is from that zometa/estrogen article. With my incredibly dense bones (probably caused by childhood fluoride pills), I'm sure I have lots of blasts to keep the dtc's nourished: Another possibility is that the bone microenvironment in estrogen-exposed women better supports the survival and expansion of disseminated tumor cells in the endosteal niche. This idea is supported by the findings that estrogen increases the number and activity of endosteal osteoblasts [22], which are critical mediators of stem cell dormancy and survival [23]; estrogen may thereby impede the ability of ZA to decrease disseminated tumor cells.The zometa isn't going to work.

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khagihara

Post-Doctoral Degree

 
5,404 satisfied customers
Dr. Love (please do NOT answer if you are not Dr.

Dr. Love (please do NOT answer if you are not Dr. Love),I'm getting more and more worried that the zometa won't kill the DTC's because of my dense bones:There is increasing evidence that ZA could affect survival of disseminated tumor cells, whose prevalence predicts local and distant relapse [14]. Both neoadjuvant and postchemotherapy administration of ZA (and other bisphosphonates) have been shown to decrease disseminated tumor cells in marrow compared with pretreatment levels [15,16], lowering the risk of metastatic spread from micrometastases. This occurrence could represent an anti-cancer effect. Interestingly, osteoclasts and osteoblasts have been implicated in the maintenance of dormant leukemic clones in the marrow [17], which may also be the case for breast cancer. Moreover, breast tumor cell viability in the endosteal niche has been shown to involve heterotypic notch/jagged interactions with osteoblasts similar to those used to regulate hematopoietic stem cell numbers [18,19]. ZA-mediated shifts in osteoclast and osteoblast function may therefore lead to changes in the microenvironment that undermine support for disseminated cancer cells.Help!

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Dr. D. Love

Doctoral Degree

 
14,732 satisfied customers
I have had ms since 17 now 52. Diagnosed 27. In wheelchair.

I have had ms since 17 now 52. Diagnosed 27. In wheelchair. Supra public catheter. When was RR had cortisone drips for relapse. Would stem cell treatment help.regain function?

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Dr. SH

Board Certified Physician

Doctoral Degree

 
13,926 satisfied customers
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