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Welcome and thank you for your question.Yes, you can either increase your payroll tax withholding or pay estimated taxes to cover the tax liability. Will your wife be working as an I/C for one company or organization?
Yes, she will be working as an IC for one company.
Then the easiest way is estimate her tax liability and increase your withholding. Please keep in mine that she will also be subject to self-employment tax and will need to report the 1099 Misc she receives from the organization for her services on Schedule C in the Form 1040.